1188296-52-7
中文名稱
無中文名稱
英文名稱
PF 4800567 hydrochloride
CAS
1188296-52-7
分子式
C17H18ClN5O2
分子量
359.81
MOL 文件
1188296-52-7.mol
更新日期
2025/04/03 17:37:07
1188296-52-7 結(jié)構(gòu)式
基本信息
中文別名
化合物PF-4800567PF-4800567游離態(tài)
3-[(3-氯苯氧基)甲基]-1-(四氫-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺
英文別名
PF 4800567PF 4800567
PF-4800567
PF 4800567 hydrochloride
3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine
3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-
3-[(3-Chlorophenoxy)Methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Hydrochloride
所屬類別
生物：小分子化合物物理化學(xué)性質(zhì)
沸點(diǎn)592.9±50.0 °C(Predicted)
密度1.52±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
酸度系數(shù)(pKa)4.01±0.30(Predicted)
形態(tài)結(jié)晶固體
顏色Light yellow to yellow
應(yīng)用領(lǐng)域
用途1
PF 4800567 is a selective casein kinase 1蔚 inhibitor; displays 22-fold greater potency towards CK1蔚 than CK1δ (IC50 values are 32 and 711 nM for CK1蔚 and CK1δ respectively). ATP competitive. Displays
minimal effect on the circadian clock.PF 4800567價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-12470 | PF-4800567 | 1188296-52-7 | 1 mg | 335元 |
| 2025/02/08 | HY-12470 | 3-((3-氯苯氧基)甲基)-1-(四氫-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺 PF-4800567 | 1188296-52-7 | 5mg | 800元 |
| 2025/02/08 | HY-12470 | 3-((3-氯苯氧基)甲基)-1-(四氫-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺 PF-4800567 | 1188296-52-7 | 10mM * 1mLin DMSO | 880元 |
常見問題列表
生物活性
PF 4800567是casein kinase 1 epsilon (IC50=32 nM) 的新型有效抑制劑，其選擇性是casein kinase 1 delta(IC50=711 nM)的20倍以上。靶點(diǎn)
| Target | Value |
|
casein kinase 1 epsilon
(Cell-free assay) | 32 nM |
|
casein kinase 1 delta
() | 711 nM |
體外研究
PF-4800567 is a potent and selective inhibitor of casein kinase 1? (CK1?), with an IC 50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC 50 , 711 nM). PF-4800567 shows inhibitory activity against CK1? and CK1δ in whole cells, with IC 50 s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1?-mediated PER3 nuclear localization mediated by CK1? and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 has little effect on the circadian clock at 32 nM.
體內(nèi)研究
PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice.