117423-74-2
117423-74-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15803 英文別名
CGS23131LY 223982
SKF107324)
LY223982 Exclusive
SYZSSLLFRVDRHL-QPJJXVBHSA-N
LY223982 (Synonyms: CGS23131
5-(3-Carboxybenzoyl)-2-[(E)-6-(4-methoxyphenyl)-5-hexenyloxy]benzenepropanoic acid
Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-
物理化學(xué)性質(zhì)
熔點(diǎn)151-152 °C
沸點(diǎn)753.8±60.0 °C(Predicted)
密度1.235±0.06 g/cm3(Predicted)
儲存條件-20°C冷凍
溶解度氯仿（微溶、加熱、超聲處理）、DMSO（微溶）
酸度系數(shù)(pKa)3.81±0.10(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
常見問題列表
生物活性
LY223982 是一種有效的，特異性的白三烯 B4 受體 (leukotriene B4 receptor)抑制劑，能夠有效抑制 [3H]LTB4 與 LTB4 受體結(jié)合，IC50 值為 13.2 nM。靶點(diǎn)
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LTB 4 13.2 nM (IC 50 ) |
體外研究
LY223982 is a potent and specific inhibitor of leukotriene B4 (LTB4) receptor, with an IC 50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. LY223982 is also a potent antagonist of the aggregation of human neutrophils by LTB4 (IC 50 , 100 nM).
體內(nèi)研究
LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED 50 , 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems.