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117041-96-0

中文名稱 TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
英文名稱 Trisodium (2RS,3RS)-2-methylcitrate
CAS 117041-96-0
分子式 C7H7O7*3Na
分子量 230.15
MOL 文件 117041-96-0.mol
117041-96-0 結構式 117041-96-0 結構式

基本信息

中文別名
2-甲基檸檬酸三鈉 非標記非對映異構體的混合物 90%+ CP
2-甲基檸檬酸三鈉 非對映異構體的混合物 (甲基-D3, 98%) 90%+ CP
英文別名
Methylcitric acid trisodium
2-Methylcitric acid trisodium
2-hydroxy-butane-1,2,3-tricarbonoic acid
TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
Trisodium 2-methylcitrate, racemic mixture of diastereomers >=85% (mixture of diastereomers, NMR)

物理化學性質

儲存條件-20°C儲存
形態(tài)Solid
顏色White to off-white

安全數(shù)據(jù)

WGK Germany3

常見問題列表

生物活性
2-Methylcitric acid trisodium (Methylcitric acid trisodium) 是 2- 甲基檸檬酸循環(huán)的內源性代謝物。2-Methylcitric acid trisodium 在甲基丙二酸血癥和丙二酸酸血癥中積累并能作為代謝標志物。2-Methylcitric acid trisodium 對谷氨酸支持的線粒體中 ADP 刺激和不耦合呼吸作用有明顯的抑制作用。
靶點

Human Endogenous Metabolite

體外研究

2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria.
2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca 2+ -loaded mitochondria supported by different substrates.
2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis.
2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport.
2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria.

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