Calcium Channel

AE0047 Hydrochloride (4e) is a calcium antagonist. AE0047 inhibits [ ³ H]nimodipine binding to rat cardiac membrane homogenate with an IC ₅₀ of 0.26 nM. AE0047 (1 μM) inhibits the high K ⁺ -evoked vascular smooth muscle contraction, and also inhibits [ ³ H]PN200-110 binding with a K _i of 40.9 nM.

AE0047 (3 mg/kg) shows antihypertensive effect, and reduces systolic blood pressure with ED ₃₀ of 1.1 mg/kg. AE0047 (1 or 3 mg/25g SP diet) inhibits blood pressure elevation and improves endothelium-dependent relaxation in response to acetylcholine in aorta isolated from stroke-prone spontaneously hypertensive rats (SHRSP).