1158279-20-9
中文名稱
無(wú)中文名稱
英文名稱
HLCL-61 (hydrochloride)
CAS
1158279-20-9
分子式
C23H25ClN2O
分子量
380.92
MOL 文件
1158279-20-9.mol
1158279-20-9 結(jié)構(gòu)式
基本信息
中文別名
HLCL-61 鹽酸鹽PRMT5抑制劑(HLCL-61 HYDROCHLORIDE)
英文別名
CS-2798HLCL-61.HCl
HLCL61
HLCL 61
HLCL-61 (hydrochloride)
HLCL61
HLCL 61
HLCL 61 HYDROCHLORIDE
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件Inert atmosphere,Store in freezer, under -20°C
溶解度≥20.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
形態(tài)結(jié)晶固體
顏色White to off-white
HLCL-61 鹽酸鹽價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-100025A | 1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基芐基)甲胺鹽酸鹽 HLCL-61 hydrochloride | 1158279-20-9 | 5mg | 500元 |
| 2024/11/08 | HY-100025A | 1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基芐基)甲胺鹽酸鹽 HLCL-61 hydrochloride | 1158279-20-9 | 10mM * 1mLin DMSO | 550元 |
| 2024/11/08 | HY-100025A | 1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基芐基)甲胺鹽酸鹽 HLCL-61 hydrochloride | 1158279-20-9 | 10mg | 750元 |
常見(jiàn)問(wèn)題列表
生物活性
HLCL-61 hydrochloride 是首創(chuàng)的小分子蛋白精氨酸甲基轉(zhuǎn)移酶 5 (PRMT5) 抑制劑。靶點(diǎn)
Protein arginine methyltransferase 5
體外研究
HLCL-61 hydrochloride (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC
50
s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively.
HLCL-61 hydrochloride shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12?h post-treatment and persisting after 48?h.
Cell Viability Assay
| Cell Line: | MV4-11 cells, THP-1 cells, FLT3-WT blast (primary blasts from patients), FLT3-ITD blast (primary blasts from patients) |
| Concentration: | 1, 5, 10, 25, 50, 100 μM |
| Incubation Time: | 24, 48, 72 hours |
| Result: | Dose-dependent reduction in cell viability with IC 50 s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively. |