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115534-33-3

中文名稱 TMA-DPH(疏水膜熒光探針)
英文名稱 TMA-DPH
CAS 115534-33-3
分子式 C28H31NO3S
分子量 461.62
MOL 文件 115534-33-3.mol
更新日期 2024/12/23 17:38:45
115534-33-3 結(jié)構(gòu)式 115534-33-3 結(jié)構(gòu)式

基本信息

中文別名
膜電位熒光探針TMA-DPH
TMA-DPH(疏水膜熒光探針)
英文別名
TMA-DPH
TMA-DPH *CAS#: 115534-33-3*
4'-(Trimethylammonio)diphenylhexatrien
4'-(TRIMETHYLAMMONIO)DIPHENYLHEXATRIENE
1-(4-TRIMETHYLAMMONIUMPHENYL)-6-PHENYL-1 ,3,5-HEXAT
1,6-DIPHENYL-1,3,5-HEXATRIENE-4'-TRIMETHYLAMMONIUM TOSYLATE
4'-(Trimethylammonio)diphenylhexatriene p-toluenesulfonate
N,N,N-TRIMETHYL-4-[6-PHENYLHEXATRIEN-1-YL]PHENYLAMMONIUM TOSYLATE
1-(4-Trimethylammoniophenyl)-6-phenyl-1,3,5-hexatriene p-toluenesulfonate
1-(4-TRIMETHYLAMMONIUMPHENYL)-6-PHENYL-1,3,5-HEXATRIENE P-TOLUENESULFONATE

物理化學(xué)性質(zhì)

熔點237 °C (dec.)(lit.)
儲存條件−20°C
溶解度DMF: soluble
形態(tài)A crystalline solid
顏色Off-white to light brown

安全數(shù)據(jù)

危險品標(biāo)志T
危險類別碼61
安全說明53-45
WGK Germany3
F8

常見問題列表

生物活性
TMA-DPH 是一種疏水性熒光膜探針 (Ex=355 nm; Em=430 nm)。
體外研究

In contact with cells, TMA-DPH is instantaneously incorporated into the plasma membrane. TMA-DPH is concentrated in lysosomes and highly acidic late endosomes. The TMA-DPH fluorescence lifetime remains constant, 6.2±0.2 ns, below the same critical concentration of 2 μM, but decreases significantly with higher concentrations. This decrease, however, slows down above 5 μM. The TMA-DPH fluorescence anisotropy displays a similar evolution to the fluorescence lifetime. It is first constant, 0.283±0.003, again until 2 μM, and then decreases rapidly to 0.270±0.003 with 5 μM, continuing to fall, but at a lower rate with higher concentrations.

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