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1135237-88-5

中文名稱 EXHERIN
英文名稱 Exherin (trifluoroacetate)
CAS 1135237-88-5
分子式 C24H35F3N8O8S2
分子量 684.709
MOL 文件 1135237-88-5.mol
更新日期 2024/10/20 11:23:30
1135237-88-5 結(jié)構(gòu)式 1135237-88-5 結(jié)構(gòu)式

基本信息

中文別名
ADH-1三氟乙酸鹽
化合物EXHERIN TRIFLUOROACETATE
英文別名
ADH-1 trifluroacetate
ADH-1 TRIFLUOROACETATE
Exherin (trifluoroacetate)
所屬類(lèi)別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO:43.0(Max Conc. mg/mL);62.8(Max Conc. mM)
形態(tài)Solid
顏色White to off-white
EXHERIN價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19HY-13541AEXHERIN
ADH-1 trifluoroacetate
1135237-88-55mg1100元
2024/08/19HY-13541AEXHERIN
ADH-1 trifluoroacetate
1135237-88-510mg1800元
2024/08/19HY-13541AEXHERIN
ADH-1 trifluoroacetate
1135237-88-550mg4500元

常見(jiàn)問(wèn)題列表

生物活性
ADH-1 trifluoroacetate是選擇性和競(jìng)爭(zhēng)性的N-鈣粘蛋白拮抗劑,具有潛在抗腫瘤和抗血管生成活性。
體外研究

ADH-1 (0.2 mg/mL) blocks collagen I-mediated changes in pancreatic cancer cells, and is highly effective at preventing cell motility that is induced by expression of N-cadherin. ADH-1 (0, 0.1, 0.2, 0.5 and 1.0 mg/mL) induces apoptosis in a dose-dependent and N-cadherin-dependent manner.

體內(nèi)研究

ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells. ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model. ADH-1 (10 mL/kg, i.p.) augmentation of melanoma tumor growth is overcome through its ability to make regionally infused melphalan more effective. ADH-1 mediated augmentation of melanoma tumor growth is not altered by regionally infused temozolomide. In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts.

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