1135237-88-5
基本信息
化合物EXHERIN TRIFLUOROACETATE
ADH-1 TRIFLUOROACETATE
Exherin (trifluoroacetate)
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/08/19 | HY-13541A | EXHERIN ADH-1 trifluoroacetate | 1135237-88-5 | 5mg | 1100元 |
2024/08/19 | HY-13541A | EXHERIN ADH-1 trifluoroacetate | 1135237-88-5 | 10mg | 1800元 |
2024/08/19 | HY-13541A | EXHERIN ADH-1 trifluoroacetate | 1135237-88-5 | 50mg | 4500元 |
常見(jiàn)問(wèn)題列表
ADH-1 (0.2 mg/mL) blocks collagen I-mediated changes in pancreatic cancer cells, and is highly effective at preventing cell motility that is induced by expression of N-cadherin. ADH-1 (0, 0.1, 0.2, 0.5 and 1.0 mg/mL) induces apoptosis in a dose-dependent and N-cadherin-dependent manner.
ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells. ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model. ADH-1 (10 mL/kg, i.p.) augmentation of melanoma tumor growth is overcome through its ability to make regionally infused melphalan more effective. ADH-1 mediated augmentation of melanoma tumor growth is not altered by regionally infused temozolomide. In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts.