1126602-42-3
中文名稱(chēng)
AG311
英文名稱(chēng)
AG311
CAS
1126602-42-3
分子式
C17H15N5S
分子量
321.4
MOL 文件
1126602-42-3.mol
1126602-42-3 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
AG311 is a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. In vitro, AG311 induces rapid necrosis in numerous cancer cell lines. Within minutes, exposure to AG311 also results in mitochondrial depolarization, superoxide production, and increased intracellular calcium levels. AG311 retards tumor growth and reduces lung metastases better than clinically used agents and has no gross or histopathological toxicity. AG311 is a first-in-class antitumor and antimetastatic agent inducing necrosis in breast cancer tumors, likely through the mitochondria.