112208-01-2
中文名稱
化合物PAM3CSK4 TFA
英文名稱
Pam3Cys-Ser-(Lys)4 TFA
CAS
112208-01-2
分子式
C83H157F3N10O15S
分子量
1624.28
MOL 文件
112208-01-2.mol
112208-01-2 結(jié)構(gòu)式
基本信息
中文別名
化合物PAM3CSK4 TFA 英文別名
Pam3CSK4 TFAPam3Cys-Ser-(Lys)4 TFA
Pam3CSK4 TFA (112208-00-1 free base)
Pam3CSK4 TFA (112208001 free base),Pam3CSK4,Toll-like Receptor (TLR),Pam-3CSK4 TFA (112208-00-1 free base),Inhibitor,inhibit,Pam3CSK4 TFA (112208 00 1 free base)
物理化學(xué)性質(zhì)
儲存條件-20°C, away from moisture
溶解度DMSO : ≥ 50 mg/mL (26.99 mM)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Pam3CSK4 TFA 是一種 Toll 樣受體 1/2 (TLR1/2) 激動劑，對人 TLR1/2 的 EC50 為 0.47 ng/mL。體外研究
Pam3CSK4 is a TLR1/2 heterodimer recognises triacylated lipopeptides.
Pam3CSK4 (1 μg/mL) enhances the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils to Methicillin-resistant
Staphylococcus aureus
(MRSA).
體內(nèi)研究
Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice.
| Animal Model: | Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2 tm1Kir /J (TLR2 -deficient) mice |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneally (i.p.); once a day for 9 days |
| Result: | After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12. |