111686-79-4
中文名稱
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
英文名稱
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
CAS
111686-79-4
分子式
C17H21ClN2O
分子量
304.81
MOL 文件
111686-79-4.mol
111686-79-4 結(jié)構(gòu)式
基本信息
中文別名
鹽酸瑞馬酰胺 英文別名
pr934-423afpl12924aa
RemacemideHCl
REMACEMIDE HYDROCHLORIDE
2-AMino-N-(1,2-diphenylpropan-2-yl)acetaMide hydrochloride
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
2-diphenylethyl)acetamidemonohydrochloride(+-)-2-amino-n-(1-methyl-
2-amino-n-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(+-)-acetamid
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H302-H318-H400
危險(xiǎn)品標(biāo)志Xn,N
危險(xiǎn)類別碼22-41-50/53
安全說(shuō)明26-39-45-60-61
危險(xiǎn)品運(yùn)輸編號(hào)UN 3077 9 / PGIII
WGK Germany3
RTECS號(hào)AB4349500
毒性LD50 (calculated as base) in rats (mg/kg): ~50 i.v., ~900 orally (Muir, Palmer)
常見(jiàn)問(wèn)題列表
生物活性
Remacemide hydrochloride (FPL 12924AA) 是一種鈉離子通道的中等強(qiáng)度抑制劑，是 N-methyl-D-aspartate (NMDA) 受體 的弱無(wú)競(jìng)爭(zhēng)力拮抗劑，對(duì)于 MK-801 結(jié)合的 IC50 值為 68 μM，對(duì)于 NMDA 電流的 IC50 值為 76 μM。Remacemide hydrochloride 是一種抗驚厥劑。靶點(diǎn)
IC50: 68-76 μM (NMDA receptor)
IC50:160.6 μM(sodium channel)
體外研究
Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na + channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC 50 value of 160.6 μM.
體內(nèi)研究
Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats.
| Animal Model: | Female Sprague–Dawley rats ( 190-210 g ) |
| Dosage: | 100 mg/kg and 150 mg/kg |
| Administration: | Orogastric gavage; once a day; 7 days |
| Result: | Increased the number of sessions required to complete audio/visual discrimination (AVD) training. |