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11076-29-2

中文名稱(chēng) Streptomyces pepsin inhibitor
CAS 11076-29-2
分子式 C31H57N5O9
分子量 643.81
MOL 文件 11076-29-2.mol
11076-29-2 結(jié)構(gòu)式 11076-29-2 結(jié)構(gòu)式

基本信息

中文別名
乙酰胃泌素
英文別名
Pepsidin c
Pepstatin AC
Streptomyces pepsin inhibitor
acetyl pepstatin|acetyl-pepstatin
N-Ac-L-Val-L-Val-Sta-L-Ala-Sta-OH
Ac-Val-val-4-amino-3-hydroxy-6-me-heptanoyl-Ala-4-amino-3-hydroxyl-6-me-heptanoic acid
Acetylvalylvalyl-4-amino-3-hydroxy-6-methylheptanoylalanyl-4-amino-3-hydroxyl-6-methylheptanoic acid
N-Acetyl-L-Val-L-Val-[(3S,4S)-4-amino*-3-hydroxy-6-methylheptanoyl]-L-Ala-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]NH2
L-Alaninamide, N-acetyl-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]-
L-Alaninamide, N-acetyl-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]- (9ci)

物理化學(xué)性質(zhì)

熔點(diǎn)223-225 °C
沸點(diǎn)992.8±65.0 °C(Predicted)
密度1.142±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)4.17±0.10(Predicted)

常見(jiàn)問(wèn)題列表

生物活性
Acetyl-pepstatin 是一種強(qiáng)效的異嗜性鼠白血病病毒相關(guān)病毒 (XMRV) 蛋白酶 (PRs) 和 HIV-1 PR 抑制劑,Ki 分別為 712 和 13 nM。
體外研究

Inhibition of the XMRV PR-mediated cleavage of a recombinant murine leukemia virus (MLV) Gag fragment by Acetyl-pepstatin (3.1 μM).

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