11016-15-2
基本信息
C-藻藍素
C-藻藍蛋白
藻藍素E25
藻藍蛋白,(藻藍素)
異藻藍蛋白(APC)
藻藍蛋白(源頭工廠)
藻藍蛋白E25.E18
C-PC(C-藻藍蛋白)
C-藻藍蛋白 來源于螺旋藻
Phycocaynin
PHYCOCYANIN C
C-PHYCOCYANIN
C-phycocyamin
Phycocyanins, C-
C-Phycocyanin (C-PC)
C-PC (C-Phycocyanin)
Phycocyanin,Spirulina blue
Spirulina Blue—Phycocyanin
安全數(shù)據(jù)
常見問題列表
藻藍蛋白是從螺旋藻中分離出的一種深藍色粉末，色澤美觀。它既是一種蛋白質(zhì)，又是一種極好的天然食用色素，同時又是良好的保健食品。
藻藍蛋白是一種細胞內(nèi)蛋白，通過破碎螺旋藻細胞溶入提取液沉淀后分離得到，因為提取后呈藍色，故名藻藍蛋白。很多人聽到這里會認為藻藍蛋白不過是一種螺旋藻中提取的天然色素，忽略了藻藍蛋白含有八種人體必需氨基酸，攝入藻藍蛋白對人體大有裨益。
藻藍蛋白的應(yīng)用研究很普遍，可歸納以下幾方面：
(1)天然食用色素：藻藍蛋白是水溶性色素，純藍，清亮可愛，可作為食品著色劑、化妝品的添加劑。而且本身是非常豐富的蛋白質(zhì)。
(2)醫(yī)藥保健食品：藻藍蛋白離體實驗證明具有刺激紅細胞集落生成，類似紅細胞生成素(EPO)的作用。藻藍蛋白可以幫助調(diào)節(jié)合成人體所需要的多種重要酶，對抑制癌細胞的生長具有重要作用，同時還可以調(diào)節(jié)人體的免疫系統(tǒng)，增強免疫系統(tǒng)的功能，提高人體對疾病的抵抗能力。
(3)化妝品領(lǐng)域：藻藍蛋白是類膠原蛋白， 具有抗氧化，保濕抗過敏，祛斑等功效。
(4)生物學(xué)、化學(xué)和細胞學(xué)實驗的特殊試劑：藻藍蛋白藍色并有熒光，可作為生物學(xué)、細胞學(xué)一些光動力學(xué)的研究試劑。 也可作為生化標記使用。
鹽析法：鹽在水溶液中電離形成的正負離子可吸引水分子，從而破壞蛋白質(zhì)的水花膜，中和部分電荷，致使蛋白質(zhì)聚集沉淀，并從溶液中析出。由于各種蛋白顆粒的大小、所帶電荷的多少及其親水程度的不同當使用某種中性鹽進行鹽析時，所需的最低鹽濃度各不相同。
DEAE一纖維素：英文名稱DEAE - Cellulose，二乙基胺乙基纖維素，總交換量0.9meq/g功能基：二乙基胺乙基弱堿性陰離子交換劑。原理：含有某些功能基團，可以進行離子交換。性能比一般離子交換樹脂溫和，適用于分離具有生物活性的大分子，可以將性質(zhì)相近的大分子物質(zhì)分開。
For the combination experiments, when cells treated with All-trans retinoic acid (ATRA) combined with C-phycocyanin, the IC 50 value is lower than that in ATRA group. But under the same IC 50 , the more C-phycocyanin is used, the less ATRA is needed. Results demonstrate that C-phycocyanin combined with ATRA can significantly decrease CDK-4 mRNA level (P<0.05). The combination index (CI) value of the C-phycocyanin+ATRA combination group is 0.852 which is less than 1, indicating that the two drugs are synergetic under the action concentration (88 μg/L C-phycocyanin+0.102 mM ATRA). Compare with control group, the Integrated optical density (IOD) in C-phycocyanin or ATRA treated group is increased, and the differences are statistically significant (P<0.05) and the differences are further exaggerated in combination group (P<0.01). The expression of caspase-3 in C-phycocyanin group is more than that in the control group but is similar to that in ATRA group, whereas the expression in combination group is maximum.
Compare with control group, the average tumor weights of mice in solely C-phycocyanin or ATRA treatment groups are significantly decreased, and further reduced in C-phycocyanin+ATRA synergy group. Results show that single C-phycocyanin can increase the spleen weight of mice but the effects of ATRA are just opposite. C-phycocyanin can also promote the growth of immune organs in mice and increase the body's immune function. C-phycocyanin and ATRA alone can significantly inhibit Cyclin D1 expression, and when being combined, the inhibitory effect is more obvious.