108477-18-5
中文名稱
108477-18-5
英文名稱
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
CAS
108477-18-5
分子式
C19H14N2O7S
分子量
414.39
MOL 文件
108477-18-5.mol
108477-18-5 結構式
基本信息
中文別名
半胱天冬酶和細胞凋亡激活劑(UBIQUITIN ISOPEPTIDASE INHIBITOR I, G5) 英文別名
NSC-144303Ubiquitin Isopeptidase-IN-G5
Ubiquitin Isopeptidase Inhibitor I
G5, Ubiquitin Isopeptidase Inhibitor I
Ubiquitin Isopeptidase Inhibitor I, G5
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303)
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
物理化學性質
熔點233.5-234.5 °C
沸點693.0±55.0 °C(Predicted)
密度1.541±0.06 g/cm3(Predicted)
儲存條件Store at -20°C,unstable in solution, ready to use.
溶解度≤15mg/ml in DMSO;1mg/ml in dimethyl formamide
形態(tài)結晶固體
顏色Light yellow to yellow
108477-18-5價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 5mg | 770元 |
| 2024/11/08 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 10mg | 1330元 |
| 2024/11/08 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 25mg | 2660元 |
常見問題列表
生物活性
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依賴的半胱天冬酶和細胞凋亡的激活劑，對E1A和E1A/C9DN細胞的IC50值分別為1.76和1.6 μM。靶點
IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells)
體外研究
G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC 50 s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.