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108433-95-0

中文名稱 MAGAININ 2抗菌肽
英文名稱 MAGAININ II
CAS 108433-95-0
分子式 C114H180N30O29S
分子量 2466.9
MOL 文件 108433-95-0.mol
更新日期 2024/12/23 14:07:09
108433-95-0 結構式 108433-95-0 結構式

基本信息

中文別名
蛙皮素II
GS-23
蛙皮素 2
馬蓋寧 II
定制肽/23肽
MAGAININ 2肽
MAGAININ 2抗菌肽
英文別名
MAGAININ 2
Aids007842
MAGAININ II
Aids-007842
Magainin II peptide
MAGAININ II USP/EP/BP
GIGKFLHSAKKFGKAFVGEIMNS
Magainin II, ≥97% (HPLC)
Magainin 2 (Xenopus laevis)
Magainin 2 peptide, Xenopus
所屬類別
生物化工:多肽

物理化學性質

沸點2444.0±65.0 °C(Predicted)
密度1.275±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度溶于二甲基亞砜
形態(tài)Solid
顏色White to off-white
序列H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser-OH

安全數(shù)據(jù)

WGK Germany3
WGK Germany3
蛙皮素2價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2024/11/08HY-P0270MAGAININ 2抗菌肽
Magainin 2
108433-95-0500μg900元
2024/11/08HY-P0270MAGAININ 2抗菌肽
Magainin 2
108433-95-01mg1600元
2024/11/08HY-P0270MAGAININ 2抗菌肽
Magainin 2
108433-95-05mg3400元

常見問題列表

生物活性
Magainin 2 (Magainin II) 是一種抗菌肽 (AMP),從非洲爪蟾皮膚中分離得到。Magainin 2 顯示抗生素活性對許多革蘭氏陰性和革蘭氏陽性細菌。Magainin 2 對原生動物也有活性。Magainin 2 通過優(yōu)先與細菌膜中豐富的陰離子磷脂相互作用而發(fā)揮細胞毒性作用。
體外研究

Magainin 2 exhibits bactericidal effects and induces morphological changes in Escherichia coli regarding early apoptosis. Magainin 2 induces the expression of a bacterial protein with affinity for the caspase substrate and effects the expression of RecA as a caspase-like protein. Magainin 2 kill bacteria by permeabilizing the cell membranes without exhibiting significant toxicity against mammalian cells. The main target of the peptide is considered to be the lipid matrix of the membranes. Application of 10 μg /mL magainin 2 to Paramecium caudatum, a protozoan, in pond water caused an osmotic swelling of the cell and a subsequent cell burst, suggesting that the peptide could perturb membrane functions responsible for osmotic balance. Magainin 2 permeabilizes bacterial and mammalian membranes in significantly different ways. The peptide forms pores with a diameter of about 2.8 nm (less than 6.6 nm) in B. megaterium , and translocates into the cytosol. In contrast, the peptide significantly perturbes the membrane of CHO-K1 cells, permitting the entry of a large molecule (larger than 23 nm) into the cytosol, accompanied by membrane budding and lipid flip-flop, mainly accumulating in mitochondria and nuclei.

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