108433-95-0
基本信息
GS-23
蛙皮素 2
馬蓋寧 II
定制肽/23肽
MAGAININ 2肽
MAGAININ 2抗菌肽
Aids007842
MAGAININ II
Aids-007842
Magainin II peptide
MAGAININ II USP/EP/BP
GIGKFLHSAKKFGKAFVGEIMNS
Magainin II, ≥97% (HPLC)
Magainin 2 (Xenopus laevis)
Magainin 2 peptide, Xenopus
物理化學性質
報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-P0270 | MAGAININ 2抗菌肽 Magainin 2 | 108433-95-0 | 500μg | 900元 |
2024/11/08 | HY-P0270 | MAGAININ 2抗菌肽 Magainin 2 | 108433-95-0 | 1mg | 1600元 |
2024/11/08 | HY-P0270 | MAGAININ 2抗菌肽 Magainin 2 | 108433-95-0 | 5mg | 3400元 |
常見問題列表
Magainin 2 exhibits bactericidal effects and induces morphological changes in Escherichia coli regarding early apoptosis. Magainin 2 induces the expression of a bacterial protein with affinity for the caspase substrate and effects the expression of RecA as a caspase-like protein. Magainin 2 kill bacteria by permeabilizing the cell membranes without exhibiting significant toxicity against mammalian cells. The main target of the peptide is considered to be the lipid matrix of the membranes. Application of 10 μg /mL magainin 2 to Paramecium caudatum, a protozoan, in pond water caused an osmotic swelling of the cell and a subsequent cell burst, suggesting that the peptide could perturb membrane functions responsible for osmotic balance. Magainin 2 permeabilizes bacterial and mammalian membranes in significantly different ways. The peptide forms pores with a diameter of about 2.8 nm (less than 6.6 nm) in B. megaterium , and translocates into the cytosol. In contrast, the peptide significantly perturbes the membrane of CHO-K1 cells, permitting the entry of a large molecule (larger than 23 nm) into the cytosol, accompanied by membrane budding and lipid flip-flop, mainly accumulating in mitochondria and nuclei.