108237-91-8
中文名稱
108237-91-8
英文名稱
4-bromo-phenyl-(4-phenyl-thiazol-2-yl)-amine
CAS
108237-91-8
分子式
C15H11BrN2S
分子量
331.23
MOL 文件
108237-91-8.mol
更新日期
2024/11/01 21:59:59
108237-91-8 結(jié)構(gòu)式
基本信息
中文別名
化合物RCGD423N-(4-溴苯基)-4-苯基噻唑-2-胺
英文別名
RCGD423RCGD 432
2-Thiazolamine, N-(4-bromophenyl)-4-phenyl-
4-bromo-phenyl-(4-phenyl-thiazol-2-yl)-amine
物理化學(xué)性質(zhì)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,2-8°C
儲(chǔ)存條件under inert gas (nitrogen or Argon) at 2–8 °C
溶解度DMSO:34.0(Max Conc. mg/mL);102.6(Max Conc. mM)
Ethanol:34.0(Max Conc. mg/mL);102.6(Max Conc. mM)
Ethanol:34.0(Max Conc. mg/mL);102.6(Max Conc. mM)
形態(tài)固體
顏色Light yellow to yellow
N-(4-溴苯基)-4-苯基噻唑-2-胺價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-114775 | 108237-91-8 RCGD423 | 108237-91-8 | 5mg | 720元 |
| 2024/11/08 | HY-114775 | 108237-91-8 RCGD423 | 108237-91-8 | 10mM * 1mLin DMSO | 792元 |
| 2024/11/08 | HY-114775 | 108237-91-8 RCGD423 | 108237-91-8 | 10mg | 1100元 |
常見問題列表
生物活性
RCGD-423 是 Glycoprotein 130 (gp130, IL6ST, IL6-beta, CD130) 信號(hào)調(diào)節(jié)劑，可調(diào)節(jié)軟骨生長(zhǎng)和分化。靶點(diǎn)
|
IL6-beta
|
體外研究
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
體內(nèi)研究
RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage.