1077626-51-7
1077626-51-7 結構式
基本信息
中文別名
2-((4-([1,1'-聯(lián)苯]-4-基氨基)-6-氯嘧啶-2-基)硫代)辛酸 英文別名
HZ-52MLNIGXYHGQLWLD-UHFFFAOYSA-N
2-[[4-([1,1'-biphenyl]-4-ylaMino)-6-chloro-2-pyriMidinyl]thio]octanoic Acid
Octanoic acid, 2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]-
物理化學性質
沸點625.3±55.0 °C(Predicted)
密度1.29±0.1 g/cm3(Predicted)
儲存條件2-8°C
溶解度二甲基亞砜：≥10mg/mL
酸度系數(pKa)3.03±0.21(Predicted)
形態(tài)粉末
顏色白色至米色
應用領域
用途1
A potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7μM in intact human polymorphonuclear leukocytes. It also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally.