1062648-63-8
中文名稱
化合物DMT1 BLOCKER 2
英文名稱
DMT1 blocker 2
CAS
1062648-63-8
分子式
C16H13N3O
分子量
263.29
MOL 文件
1062648-63-8.mol
1062648-63-8 結(jié)構(gòu)式
基本信息
中文別名
化合物DMT1 BLOCKER 2 英文別名
DMT1 blocker 2uptake,iron,metal,DMT1,transporter,divalent,DMT-1 blocker 2,DMT1 blocker 2,Inhibitor,inhibit,enterocytes,direct
物理化學(xué)性質(zhì)
沸點(diǎn)512.8±45.0 °C(Predicted)
密度1.35±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)7.04±0.20(Predicted)
形態(tài)Solid
顏色White to yellow
常見問題列表
生物活性
DMT1 blocker 2 是二價(jià)金屬轉(zhuǎn)運(yùn)蛋白 1 (DMT1) 的直接抑制劑，IC50 值為 0.83 μM。DMT1 blocker 2 可以阻斷體內(nèi)腸細(xì)胞的鐵攝取。靶點(diǎn)
IC50: 0.83 μM (divalent metal transporter 1)
體外研究
DMT1 blocker 2 (Compound 12f) (10 μM; 24 h) has no cytotoxic to HepG2 cells.
DMT1 blocker 2 (10 μM) inhibits 44% of CYP3A4 activity.
體內(nèi)研究
DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption.
| Animal Model: | Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage followed 1 h later by an iron challenge |
| Result: | Attenuated the post-challenge serum iron increase. |