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1041469-97-9

英文名稱 RKS-262
CAS 1041469-97-9
分子式 C15H14BrClN2O4S
分子量 433.7
MOL 文件 1041469-97-9.mol
1041469-97-9 結(jié)構(gòu)式 1041469-97-9 結(jié)構(gòu)式

基本信息

英文別名
RKS-262

應(yīng)用領(lǐng)域

用途一
RKS262 is a specific cycliCDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line assay RKS262 exhibited significant cytotoxicity in ovarian cancer cells and a variety of other cell lines exceeding effects of commercial drugs such as cisplatin, 5-FU, cyclophosphamide or sapacitabine. Various leukemia cell-lines were most sensitive (GI(50):?~?10 nM) while several non-small cell lung cancer cell lines and few cell lines from other tissues were relatively resistant (GI(50)?>?1?μM) to RKS262 treatment.
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