103926-64-3
103926-64-3 結構式
基本信息
中文別名
司匹司他4-(4,5-二氫-1H-咪唑-2-基氨基)-苯甲酸6-氨基甲?；?萘-2-基酯
英文別名
SepinostatSepimostat
Unii-5zfr16F4qq
Sepimostat [inn]
4-[[(4,5-Dihydro-1H-imidazol)-2-yl]amino]benzoic acid 6-amidino-2-naphtyl ester
Benzoic acid, 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester
常見問題列表
生物活性
Sepimostat (FUT-187 free base) 通過拮抗 NR2B N-methyl-D-aspartate 受體發(fā)揮神經保護作用， 作用位點在 NR2B 亞基的 Ifenprodil 結合位點。Sepimostat 抑制 Ifenprodil 結合的Ki 值為27.7?μM。體內研究
Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect.
| Animal Model: | Male Sprague Dawley rats weighing 150-300?g. |
| Dosage: | Intravitreal injection. |
| Administration: | 1 to 100 nmol/eye. |
| Result: | Exhibited neuroprotective effects significantly. |