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102-65-8

中文名稱 磺胺氯吡嗪鈉
英文名稱 N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO
CAS 102-65-8
分子式 C10H9ClN4O2S
分子量 284.72
MOL 文件 102-65-8.mol
更新日期 2024/12/23 11:22:53
102-65-8 結(jié)構(gòu)式 102-65-8 結(jié)構(gòu)式

基本信息

中文別名
磺胺氯吡嗪
磺胺氯毗嗪鈉
磺胺氯吡嗪鈉
磺胺氯吡嗪鈉一水合物
磺胺氯吡嗪(標(biāo)準(zhǔn)品)
磺胺氯吡嗪鈉 100MG
磺胺氯吡嗪溶液, 100PPM
N-(5-氯-3-吡嗪基)-4-氨基苯磺酰胺
英文別名
SPZ
102-65-8
sulfaclozine
Sulfalozine sodiu
Sulfalozine sodium
SULFACLOZINE SODIUM
SODIUM SULFACLOZINE
Sulfachloropyrazine
sulfachlorpyrazin sodium
SULFACHLORPYRAZINE SODIUM

物理化學(xué)性質(zhì)

熔點(diǎn)234.8-235.4 °C
沸點(diǎn)495.7±55.0 °C(Predicted)
密度1.588±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C(protect from light)
酸度系數(shù)(pKa)4.83±0.10(Predicted)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338

應(yīng)用領(lǐng)域

用途1
磺胺氯吡嗪鈉為抗球蟲(chóng)的專用磺胺藥,廣泛用于畜禽球蟲(chóng)病。本品可爭(zhēng)奪二氫葉酸合成酶影響二氫葉酸的合成,從而抑制細(xì)菌和球蟲(chóng)的生長(zhǎng)繁殖。本品對(duì)家禽球蟲(chóng)的作用特點(diǎn)與磺胺喹沙啉相似,但具更強(qiáng)的抗菌作用,甚至可治療禽霍亂及雞傷寒因此最適合球蟲(chóng)病爆發(fā)時(shí)治療用。
用途2
磺胺類抗菌藥,用于禽畜大腸桿菌和巴式桿菌感染,與甲氧芐啶與蔗糖配置而成復(fù)方磺胺氯噠嗪鈉鹽效果更加,對(duì)磺胺類藥過(guò)敏者忌用,腎功能減退者慎用。
用途3
本品為抗球蟲(chóng)的專用磺胺藥,廣泛用于畜禽球蟲(chóng)病。本品可爭(zhēng)奪二氫葉酸合成酶影響二氫葉酸的合成,從而抑制細(xì)菌和球蟲(chóng)的生長(zhǎng)繁殖。本品對(duì)家禽球蟲(chóng)的作用特點(diǎn)與磺胺喹沙啉相似,但具更強(qiáng)的抗菌作用,甚至可治療禽霍亂及雞傷寒因此最適合球蟲(chóng)病爆發(fā)時(shí)治療用。

常見(jiàn)問(wèn)題列表

生物活性
Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) 是一種抗原生動(dòng)物藥,用于球蟲(chóng)病的研究。
靶點(diǎn)

Bacterial; Parasite

體外研究

The elimination of Sulfaclozine in the three systems: UV/TiO 2 , UV/K 2 S 2 O 8 , and UV/TiO 2 /K 2 S 2 O 8 . Sulfaclozine is weakly adsorbed on the surface of TiO 2 at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO 2 , UV/K 2 S 2 O 8 , and UV/TiO 2 /K 2 S 2 O 8 in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of ? OH and SO 4 ?? radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals.

體內(nèi)研究

Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections.

Animal Model: 14 male broiler chickens (30-day-old)
Dosage: 60 mg/kg
Administration: Intravenous injection or oral administration (Pharmacokinetic Analysis)
Result: Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.
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