| Identification | More | [Name]
2-Chloro-N-methylacetamide | [CAS]
96-30-0 | [Synonyms]
2-CHLORO-N-METHYLACETAMIDE
N-METHYL-2-CHLOROACETAMIDE
OTAVA-BB BB7020410071
2-chloro-n-methyl-acetamid
Acetamide, 2-chloro-N-methyl-
alpha-Chloro-N-methylacetamide
N-Methylchloroacetamide
USAF do-35
usafdo-35 | [EINECS(EC#)]
202-497-1 | [Molecular Formula]
C3H6ClNO | [MDL Number]
MFCD00018913 | [Molecular Weight]
107.54 | [MOL File]
96-30-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
38-40°C | [Boiling point ]
112-115°C 20mm | [density ]
1.127±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
14.38±0.46(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C3H6ClNO/c1-5-3(6)2-4/h2H2,1H3,(H,5,6) | [InChIKey]
HOZLOOPIXHWKCI-UHFFFAOYSA-N | [SMILES]
C(NC)(=O)CCl | [CAS DataBase Reference]
96-30-0(CAS DataBase Reference) | [NIST Chemistry Reference]
ClCON(CH3)2(96-30-0) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RTECS ]
AB5775000 | [HazardClass ]
IRRITANT | [HS Code ]
29241990 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Acetamide, N,2-dichloro-N-methyl--->Butanamide, 2,2,3,3,4,4,4-heptafluoro-N-methyl--->2-Chloro-N,N-diethylacetamide-->Methylamine hydrochloride-->Methylamine-->Methyl chloroacetate-->1-DODECENE-->Chloroacetyl chloride-->Ethyl chloroacetate | [Preparation Products]
Omethoate-->N-METHYL-2-PIPERAZIN-1-YLACETAMIDE-->2-Dimethylamino-N-methyl-acetamide |
| Hazard Information | Back Directory | [Uses]
2-Chloro-N-methylacetamide is an intermediate used to prepare piperidinylamino pyrrolopyrimidines as selective Janus kinase inhibitors for the treatment of autoimmune diseases and organ transplant rejection. | [Synthesis]
To methylamine hydrochloride (896 mg, 13.3 mmol) and Na2C03 (5630 mg, 53 mmol) in water (26 mL) was added 2-chloroacetyl chloride (1500 mg, 13.3 mmol). The mixture was stirred at r.t. for lh and extracted with EtOAc (2x). The combined organic layers were dried over Na2S04 and concentrated to provide 2-Chloro-N-methylacetamide (1200 mg, 84%). |
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