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Cypate, a cyanine dye, is a near infrared (NIR)?fluorescent?probe for in vivo tumor imaging[1][2]. | [in vivo]
Cypate (10 nmol; IV; every 24 hours for 6 days) causes the liver to have the highest accumulation[1].
The fluorescence signal of Cypate (5 mg/kg; IV) in the tumor of mice (Balb/c mice with 4T1 cells) is weak and quickly decayed, possibly due to fast elimination of free cypate from body. Stronger fluorescence in liver and kidney is observed in free cypate group. The Cypate fluorescence signal is assessed using an IVIS Lumina imaging system (Ex-745 nm; Em-800 nm)[2].
| Animal Model: | Foxn1nu/Foxn1nu nude 2.5-month-old female mice with breast cancer cells (MDA-MB-231 Luc2)[1] | | Dosage: | 10 nmol in 100?μL PBS | | Administration: | IV; every 24 hours for 6 days | | Result: | The accumulation alone in the tumor was negligible for 24 hours after the injection.
The liver had the highest accumulation at all time points. |
| [References]
[1] Mona Doshi, et al. ?Cypate and Cypate-Glucosamine as Near-Infrared Fluorescent Probes for In Vivo Tumor Imaging. Mol Pharmacol. 2019 May;95(5):475-489. DOI:10.1124/mol.118.114199
[2] Yuanyuan Li, et al. Light-Decomposable Polymeric Micelles with Hypoxia-Enhanced Phototherapeutic Efficacy for Combating Metastatic Breast Cancer. Pharmaceutics. 2022 Jan 21;14(2):253. DOI:10.3390/pharmaceutics14020253 |
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