| Identification | Back Directory | [Name]
PF 04217903 mesylate | [CAS]
956906-93-7 | [Synonyms]
PF-04217903.MsOH
PF 04217903 mesylate
HBEMHKVWZJTVOC-UHFFFAOYSA-N
PF-04217903 Methanesulfonate
PF04217903 METHANESULFONATE;PF 04217903 METHANESULFONATE
4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol mesylate
4-[1-(6-QuinolinylMethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol Methanesulfonate
4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol methanesulfonate (1:1)
2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethan-1-ol methanesulfonate | [Molecular Formula]
C20H20N8O4S | [MDL Number]
MFCD17392584 | [MOL File]
956906-93-7.mol | [Molecular Weight]
468.489 |
| Hazard Information | Back Directory | [Uses]
PF 04217903 is highly selective, high affinity c-Met inhibitor (Ki = 6-7 nM against wild type c-Met). Displays >1000-fold selectivity for c-Met over a panel of 208 kinases. | [Biological Activity]
PF-04217903 is a highly selectivepotent inhibitor of the hepatocyte growth factor receptor c-Met. PF-04217903 inhibits endogenouswild type c-Met in A549 human lung carcinoma cells with an IC50 of 4.8 nM. The compund displays 1000-fold selectivity against a panel of 208 other kinases.''PF-04217903 is an ATP-competitive inhibitor. It elicits antiangiogenic functionality. PF-04217903 inhibits c-Met phosphorylation in xenograft models leading to partial tumor growth suppression. | [storage]
Store at +4°C |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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