| Identification | Back Directory | [Name]
3-BrB-PP1 | [CAS]
956025-99-3 | [Synonyms]
3-BrB-PP1
4-AMino-1-tert-butyl-3-(3-broMobenzyl)pyrazolo[3,4-d]pyriMidine
3-(3-bromobenzyl)-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
3-[(3-bromophenyl)methyl]-1-tert-butylpyrazolo[3,4-d]pyrimidin-4-amine
3-[(3-BroMophenyl)Methyl]-1-(1,1-diMethylethyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-[(3-bromophenyl)methyl]-1-(1,1-dimethylethyl)- | [Molecular Formula]
C16H18BrN5 | [MOL File]
956025-99-3.mol | [Molecular Weight]
360.25 |
| Chemical Properties | Back Directory | [Melting point ]
140-142°C | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Pale Beige |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine is a small molecule Akt inhibitor. The kinase Akt is a key signaling node in regulating cellular growth and survival. | [Definition]
ChEBI:3-BrB-PP1 is a member of the class of pyrazolopyrimidines that is pyrazolo[3,4-d]pyrimidin-4-amine bearing additional tert-butyl and 3-bromobenzyl substituents at positions 1 and 3 respectively. It is an ATP-competitive inhibitor of CDPK1 and AKT kinase. It has a role as an antiparasitic agent, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a pyrazolopyrimidine, a member of bromobenzenes and an aromatic amine. |
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