| Identification | Back Directory | [Name]
VK-II-36 | [CAS]
955371-66-1 | [Synonyms]
VK-II-36
6-(9H-carbazol-4-yloxymethyl)-4-[2-(2-methoxyphenoxy)ethyl]morpholin-3-one
3-Morpholinone, 6-[(9H-carbazol-4-yloxy)methyl]-4-[2-(2-methoxyphenoxy)ethyl]- | [Molecular Formula]
C26H26N2O5 | [MOL File]
955371-66-1.mol | [Molecular Weight]
446.49 |
| Chemical Properties | Back Directory | [Boiling point ]
698.6±55.0 °C(Predicted) | [density ]
1.271±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
16.54±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
VK-II-36 is a carvedilol analog that suppresses sarcoplasmic reticulum Ca2+release but does not block the β-receptor.VK-II-36 inhibits triggered activities evoked by both early and delayed after depolarizations[1]. | [References]
[1] Maruyama M, et al. Carvedilol analogue inhibits triggered activities evoked by both early and delayed afterdepolarizations. Heart Rhythm. 2013 Jan;10(1):101-7. DOI:10.1016/j.hrthm.2012.09.006 |
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