| Identification | Back Directory | [Name]
FMoc-N-Me-Cys(Trt)-OH | [CAS]
944797-51-7 | [Synonyms]
FMoc-N-Me-Cys(Trt)-OH
Fmoc-N-Me-L-Cys(Trt)-OH
FMOC-N-ME-CYS(TRT)-OH 1 G
FMOC-N-METHYL-L-CYSTEINE(TRT)
Fmoc-N-methyl-L-cysteine(Trityl)
(9H-Fluoren-9-yl)MethOxy]Carbonyl N-Me-Cys(Trt)-OH
N-α-(9-Fluorenylmethoxycarbonyl)-N-α-methyl-S-trityl-L-cysteine
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methyl-S-trityl-L-cysteine
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-S-(triphenylmethyl)-L-cysteine
L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-S-(triphenylmethyl)-
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(tritylthio)propanoic acid
(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-[(triphenylmethyl)sulfanyl]propanoic acid | [Molecular Formula]
C38H33NO4S | [MDL Number]
MFCD11973909 | [MOL File]
944797-51-7.mol | [Molecular Weight]
599.74 |
| Chemical Properties | Back Directory | [Melting point ]
234-239°C | [Boiling point ]
746.0±60.0 °C(Predicted) | [density ]
1.260±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -15°C to -25°C. | [form ]
Solid | [pka]
3.72±0.10(Predicted) | [color ]
White to off-white | [optical activity]
[α]22/D -25.0°, c = 0.5% in dichloromethane |
| Hazard Information | Back Directory | [Uses]
Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine).
It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A. | [Uses]
Fmoc-N-Me-L-Cys(Trt)-OH (CAS# 944797-51-7) is an fmoc- and trityl-protected derivative of L-cysteine (C995000) used as a building block for peptides or peptide fragments, such as the solid-phase synthesis of Triostin A. | [reaction suitability]
reaction type: Fmoc solid-phase peptide synthesis |
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