| Identification | Back Directory | [Name]
1-(3-AMINO-2-METHYL-BENZYL)-4-(2-THIOPHEN-2-YL-ETHOXY)-2-PYRIDONE | [CAS]
934628-27-0 | [Synonyms]
CG-549
CG0549
CG-0549
CG 0549
CG400549
CG-400549
CG 400549
Nilofabicin
Nilofabicin/CG-400549
Antibiotic,Nilofabicin,inhibit,Inhibitor,Bacterial
1-(3-AMINO-2-METHYL-BENZYL)-4-(2-THIOPHEN-2-YL-ETHOXY)-2-PYRIDONE
1-(3-aMino-2-Methylbenzyl)-4-(2-(thiophen-2-yl)ethoxy)pyridin-2(1H)-one
2(1H)-Pyridinone, 1-[(3-aMino-2-Methylphenyl)Methyl]-4-[2-(2-thienyl)ethoxy]- | [Molecular Formula]
C19H20N2O2S | [MDL Number]
MFCD09991584 | [MOL File]
934628-27-0.mol | [Molecular Weight]
340.44 |
| Chemical Properties | Back Directory | [Boiling point ]
607.1±55.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [solubility ]
DMSO : 100 mg/mL (293.74 mM; Need ultrasonic) | [form ]
Solid | [pka]
4.19±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Nilofabicin is an enoyl-(acyl-carrier protein) reductase (FabI) inhibitor. Nilofabicin had an MIC(90) of 0.5 microg/ml for Staphylococcus aureus strains and was more potent than either linezolid or vancomycin[1]. | [References]
[1] Jong Hwa Yum,et, al. In Vitro Activities of CG400549, a Novel FabI Inhibitor, against Recently Isolated Clinical Staphylococcal Strains in Korea. Antimicrob Agents Chemother. 2007 Jul; 51(7): 2591–2593. |
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