| Identification | Back Directory | [Name]
Akt Inhibitor X | [CAS]
925681-41-0 | [Synonyms]
10-NCP
10-DEBC HCl
Akt Inhibitor X
10-NCP
(10-DEBC
SVKSJUIYYCQZEC-UHFFFAOYSA-N
N-diethyl-10H-phenoxazine-10-butanamine
2-Chloro-N,N-diethyl-10H-phenoxazine-10-butanamine hydrochloride (1:1) | [Molecular Formula]
C20H26Cl2N2O | [MOL File]
925681-41-0.mol | [Molecular Weight]
381.34 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 100mM in water or DMSO | [Sensitive ]
Light Sensitive & Hygroscopic |
| Hazard Information | Back Directory | [Description]
Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC50 value of 1-2 μM. This compound has been shown to block IGF-1-stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC50 values of 2-5 μM. Inhibition of Akt phosphorylation by 5 μM of this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis. | [Uses]
Akt Inhibitor X is used as a cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity. | [storage]
Desiccate at +4°C | [References]
[1]. janjetovic k, vucicevic l, misirkic m, et al. metformin reduces cisplatin-mediated apoptotic death of cancer cells through ampk-independent activation of akt. european journal of pharmacology, 2011, 651(1): 41-50.
[2]. de abreu la, calixto c, waltero cf, et al. the conserved role of the akt/gsk3 axis in cell survival and glycogen metabolism in rhipicephalus (boophilus) microplus embryo tick cell line bme26. biochimica et biophysica acta (bba)-general subjects, 2013, 1830(3): 2574-2582.
[3]. brunet a, bonni a, zigmond mj, et al. akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. cell, 1999, 96(6): 857-868.
[4]. pulinilkunnil t, he h, kong d, et al. adrenergic regulation of amp-activated protein kinase in brown adipose tissue in vivo. journal of biological chemistry, 2011, 286(11): 8798-8809. |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
|