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ChemicalBook--->CAS DataBase List--->924811-53-0

924811-53-0

924811-53-0 Structure

924811-53-0 Structure
IdentificationBack Directory
[Name]

BT 18
[CAS]

924811-53-0
[Synonyms]

BT 18
Methanone, [4-[5-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)sulfonyl]-2-methoxyphenyl]-1-piperazinyl][4-fluoro-2-(trifluoromethyl)phenyl]-
[Molecular Formula]

C30H31F4N3O6S
[MDL Number]

MFCD19950816
[MOL File]

924811-53-0.mol
[Molecular Weight]

637.64
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 100 mg/mL (156.83 mM; Need ultrasonic)
[form ]

Solid
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2].
[Biological Activity]

BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2]. BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines[1].BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines[1].BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 μM both in GFP-transfected and in GFRD1-transfected cells[1].
[References]

[1]. Leo Jakman, Characterization of small-molecule GDNF mimics.[2]. Ivanova L, et al. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-DerivedNeurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3(9):11407-11414.
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