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ChemicalBook--->CAS DataBase List--->917909-71-8

917909-71-8

917909-71-8 Structure

917909-71-8 Structure
IdentificationBack Directory
[Name]

BIT225
[CAS]

917909-71-8
[Synonyms]

BIT225
EOS-60377
N-[5-(1-Methyl-1H-pyrazol-4-yl)-naphthalene-2-carbonyl]-guanidine
N-(Aminoiminomethyl)-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthalenecarboxamide
2-Naphthalenecarboxamide, N-(aminoiminomethyl)-5-(1-methyl-1H-pyrazol-4-yl)-
[Molecular Formula]

C16H15N5O
[MDL Number]

MFCD18633274
[MOL File]

917909-71-8.mol
[Molecular Weight]

293.32
Chemical PropertiesBack Directory
[solubility ]

DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
[form ]

Solid
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

BIT-225 is an inhibitor for Vpu protein through block of Vpu ion channel, and thus inhibits the release of HIV-1, especially in monocyte-derived macrophages (EC50 is 2.25 μM), without significant cytotoxicity (TC50 is 284 μM)[1].
[References]

[1] Khoury G, et al., Antiviral efficacy of the novel compound BIT225 against HIV-1 release from human macrophages. Antimicrob Agents Chemother. 2010 Feb;54(2):835-45. DOI:10.1128/AAC.01308-09
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