| Identification | Back Directory | [Name]
CAY10597 | [CAS]
916046-55-4 | [Synonyms]
CAY10597
2-(5-chloro-1'-(2-fluorobenzyl)-2,2',5'-trioxospiro[indoline-3,3'-pyrrolidin]-1-yl)acetic acid
5-CHLORO-1'-[(2-FLUOROPHENYL)METHYL]-2,2',5'-TRIOXO-SPIRO[3H-INDOLE-3,3'-PYRROLIDINE-1(2H)-ACETIC ACID]
Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo- | [Molecular Formula]
C20H14ClFN2O5 | [MDL Number]
MFCD11976898 | [MOL File]
916046-55-4.mol | [Molecular Weight]
416.79 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.30 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the human and murine CRTH2/DP2 receptor, respectively. The R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-prostaglandin D2 with an IC50 value of 40 nM. | [storage]
Store at -20°C |
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| Company Name: |
Resenbio
|
| Tel: |
029-86354885 |
| Website: |
www.xarxbio.com |
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