| Identification | Back Directory | [Name]
BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- | [CAS]
915759-45-4 | [Synonyms]
CS-2786
WAY 316606
WAY-316606
way-316606 /way 316606
WAY-316606;WAY 316606;WAY316606
5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide
5-(Phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C18H19F3N2O4S2 | [MDL Number]
MFCD18206894 | [MOL File]
915759-45-4.mol | [Molecular Weight]
448.48 |
| Chemical Properties | Back Directory | [Boiling point ]
601.1±65.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [solubility ]
DMF: 3 mg/ml; DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml | [form ]
Powder | [pka]
8.76±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP-1; IC50 = 0.5 μM).1 It increases Wnt signaling in U2OS osteosarcoma cells (EC50 = 0.65 μM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM.2 | [Definition]
ChEBI: WAY-316606 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonic acid with the primary amino group of piperidin-4-amine. An inhibitor of secreted Frizzled-Related Protein-1 (sFRP-1). It has a role as a secreted frizzled-related protein 1 inhibitor. It is a sulfone, a sulfonamide, a member of (trifluoromethyl)benzenes, a member of piperidines and a secondary amino compound. |
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