| Identification | Back Directory | [Name]
IndiMitecan | [CAS]
915360-05-3 | [Synonyms]
LMP-776
NSC 725776)
IndiMitecan
Indimitecan
(LMP776
GCILEJUNEYIABW-UHFFFAOYSA-N | [Molecular Formula]
C25H21N3O6 | [MDL Number]
MFCD25977123 | [MOL File]
915360-05-3.mol | [Molecular Weight]
459.45 |
| Chemical Properties | Back Directory | [Boiling point ]
782.0±60.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 8.33 mg/mL (18.13 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C) | [form ]
Solid | [pka]
6.97±0.10(Predicted) | [color ]
Brown to black |
| Hazard Information | Back Directory | [Uses]
Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities[1]. | [IC 50]
Top1 | [References]
[1] Cinelli MA, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. J Med Chem. 2012 Dec 27;55(24):10844-62. DOI:10.1021/jm300519w |
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