| Identification | Back Directory | [Name]
4-(hidroximetil)-5-metil-1,3-dioxol-2-ona | [CAS]
91526-18-0 | [Synonyms]
DMDO-OH
AZATMint-D
Azilsartan Impurity 55
Azilasartan medoximil(HPLC-98.2%)
4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one
4-(hidroximetil)-5-metil-1,3-dioxol-2-ona
4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one
4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one
4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one
1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-
4-(hydroxymethyl)-5-methyl-2H-1,3-dioxol-2-one
4-Methyl-5-hydroxyMethyl-2-oxo-1,3-dioxol-4-ene
4- (hydroxymethyl) -5- methyl -[1,3] dioxolane -2- one
4-(hidroximetil)-5-metil-1,3-dioxol-2-ona ISO 9001：2015 REACH | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C5H6O4 | [MDL Number]
MFCD12165896 | [MOL File]
91526-18-0.mol | [Molecular Weight]
130.1 |
| Chemical Properties | Back Directory | [Boiling point ]
214℃ | [density ]
1.367 | [Fp ]
93℃ | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
liquid | [pka]
14.54±0.10(Predicted) | [color ]
Pale yellow | [InChI]
InChI=1S/C5H6O4/c1-3-4(2-6)9-5(7)8-3/h6H,2H2,1H3 | [InChIKey]
JEQSUJXHFAXJOW-UHFFFAOYSA-N | [SMILES]
O1C(C)=C(CO)OC1=O |
| Hazard Information | Back Directory | [Definition]
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl) methylglyoxal chloride, which provides for an alternative approach to introduce the (oxodioxolenyl) methylcarbamate group. | [Description]
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug. | [Uses]
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is used in preparation method of key intermediate of olmesartan medoxomil. | [Preparation]
At 20-25°C, 50 g of 4-chloromethyl-5-methyl-1,3-dioxol-2-one and 45 g of formic acid were added to 500 mL of acetonitrile. The reaction was cooled to 10-15°C followed by 95 g of triethylamine added. The mixture was heated to 60-65°C and stirred for approximately 5-6 h. The reaction system was subsequently cooled to 15-20°C, filtered, and washed with acetonitrile. Collecting filtrate, and the acetonitrile was removed under vacuum to concentrate the solution. The reaction system was again cooled to 25-30°C, and ethyl acetate and water were added. The mixture was then stirred for approximately 15-20 minutes at 25-30°C. Finally, 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one was obtained after further purification.
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