| Identification | Back Directory | [Name]
Teicoplanin A2-5 | [CAS]
91032-38-1 | [Synonyms]
teicoplanin A2-5
Teichomycin A2-5
Teicoplanin A2-5
DISCONTINUED. Please see T015500
Ristomycin A aglycone, 34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(9-methyl-1-oxodecyl)amino]-β-D-glucopyranosyl]-42-O-α-D-mannopyranosyl-
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(9-methyl-1-oxodecyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosyl- | [Molecular Formula]
C89H99Cl2N9O33 | [MDL Number]
MFCD01750327 | [MOL File]
91032-38-1.mol | [Molecular Weight]
1893.68 |
| Chemical Properties | Back Directory | [density ]
1.67±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide | [form ]
lyophilisate | [pka]
2.88±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Teicoplanin A2-5 is an antibiotic against Gram positive bacteria. | [Uses]
Teicoplanin A2-5 is the most non-polar analogue of a family of lipoglycopeptides produced by Actinoplanes teichomyceticus. Teicoplanins possess potent broad spectrum antibiotic activity against Gram positive bacteria, including MRSA and E. faecalis. | [Definition]
ChEBI: A teicoplanin A2 that has 9-methyldecanoyl as the variable N-acyl group. | [Biological Activity]
teicoplanin a2-5, derived from actinoplanes teichomyceticus, is a glycopeptide antibiotic which produces a broad spectrum of antibiotic activity against gram-positive bacteria.teicoplanin a2-5 is the most non-polar metabolite in the family of teicoplanins. teicoplanin, previously referred to in the literature as teichomycin, is a mixture of five closely related components of similar polarity, designated t-a2-1, 2, 3, 4 and 5 and of one more polar component, designated t-a3. additionally, as a glycopeptide antibiotic belonging to the same family as vancomycin, teicoplanin blocks cell wall synthesis in bacillus subtilis, which is accompanied by an intracellular accumulation of udp-n-acetylmuramyl-pentapetide [1]. due to the greater antibacterial activity of teicoplanin than other agents, it has been thoroughly studied as a β-1actamase-resistant agent for the treatment of human infections caused by streptococci and staphylococci, including enterococci [2]. | [References]
[1]. somma, s., gastaldo, l., & corti, a. teicoplanin, a new antibiotic from actinoplanes teichomyceticus nov. sp. antimicrobial agents and chemotherapy. 1984; 26(6): 917-923.
[2]. traina, g., & bonati, m. pharmacokinetics of teicoplanin in man after intravenous administration. journal of pharmacokinetics and biopharmaceutics. 1984;12(2): 119-128. |
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