| Identification | Back Directory | [Name]
3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE | [CAS]
9040-59-9 | [Synonyms]
PDE 3B
EC 3.1.4.17
PHOSPHODIESTERASE
Phosphodiesterase 3B
(4-Nitrobenzyl)arsonic acid
Phosphodiesterasefrombovinebrain
Phosphodiesterase 3B, Recombinant
3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE
PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE
Phosphodiesterase, cyclic 3',5'-nucleotide
Phosphodiesterase 3A from Human, Recombinant
3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
phosphodiesterase 3':5'-cyclic*nucleotide crude C
phosphodiesterase, 3',5'-cyclic-nucleotide-specific
PHOSPHODIESTERASE 3':5'-CYCLIC*NUCLEOTID E FROM BOVI
PHOSPHODIESTERASE 3':5'-CYCLIC*NUCLEOTID E CRUDE COM
CYCLIC 3'',5''-NUCLEOTIDE PHOSPHODIESTERASE (FROM BEEF HEART)
Native Bovine Phosphodiesterase, 3,5-cyclic-nucleotide-specific
3',5'-cyclic-nucleotide 5'-nucleotidohydrolase from bovine brain
phosphodiesterase, 3',5'-cyclic-nucleotide-specific from bovine brain
Native Bovine Phosphodiesterase 3,5-Cyclic Nucleotide Activator-deficient
PDE, 3μ,5μ-Cyclic-nucleotide 5μ-nucleotidohydrolase from bovine brain
PDE, 3μ,5μ-Cyclic-nucleotide 5μ-nucleotidohydrolase from bovine heart
PDE, 3μ,5μ-Cyclic-nucleotide 5μ-nucleotidohydrolase from porcine brain
Native Porcine Phosphodiesterase, 3,5-Cyclic Nucleotide, Activator-deficient
Phosphodiesterase 3μ,5μ-Cyclic Nucleotide Activator-deficient from bovine heart
Phosphodiesterase, 3μ,5μ-Cyclic Nucleotide, Activator-deficient from porcine brain
Phosphodiesterase, 3',5'-cyclic-nucleotide-specific from bovine brain 15-30 units/mg protein (in the presence of 0.03 mM Ca2+ and a saturating level (10 units per ml) of calmodulin (P2277)), lyophilized powder | [EINECS(EC#)]
232-920-5 | [MDL Number]
MFCD00131864 |
| Hazard Information | Back Directory | [Uses]
For use in calmodulin (P 0270) assay. Activity is reduced to <50% without calmodulin present. | [Uses]
Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain has been used to assay the protein activator, calmodulin and in in vitro adenylate cyclase assay. | [General Description]
Phosphodiesterase (PDE1) exists in two isoforms -PDE1A2 and PDE1B1. The enzyme has a role in the complex interaction between cyclic nucleotides and Ca2+ second-messenger systems. | [Biochem/physiol Actions]
Hydrolyzes the 3′,5′-phosphodiester bond in cyclic nucleotide monophosphates, such as cAMP and cGMP, to the corresponding nucleotide 5′-monophosphate. | [Clinical Use]
Phosphodiesterase-3 (PDE3) is an enzyme responsible for degradation of cAMP to AMP in platelets
and blood vessels. Selective cAMP PDE3 inhibitors, such as dipyridamole and cilostazol , inhibit the degradation of cAMP, thereby increasing cellular concentration of cAMP and
leading to inhibition of platelet aggregation and vasodilation. |
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Sigma-Aldrich
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Energy Chemical
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Creative Enzymes
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SIGMA-RBI
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