| Identification | Back Directory | [Name]
CALCINEURIN | [CAS]
90371-51-0 | [Synonyms]
CAN
PP2B
PPASE-2B
CALCINEURIN
CALCINEURIN/PP2B
CALCINEURIN, HUMAN
PROTEIN PHOSPHATASE 2B
Calcineurin bovine brain
MODULATOR BINDING PROTEIN
CALMODULIN BINDING PROTEIN
CALCINEURIN FROM BOVINE BRAIN, >10 U/MG
calcium/calmodulin-activated protein phosphatase
PROTEIN PHOSPHATASE 2B, HUMAN, RECOMBINANT, E COLI | [MDL Number]
MFCD00130697 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [solubility ]
H2O: soluble | [form ]
lyophilized powder | [biological source]
bovine | [Water Solubility ]
H2O: soluble | [Specific Activity]
≥2,500units/mg protein |
| Hazard Information | Back Directory | [Uses]
Calcineurin from bovine brain has been used:
- as a positive control in western blot analysis of oocytes and cumulus cells proteome
- as a positive control in calmodulin (CaM)-agarose binding assay
- to test its phosphatase activity in the presence of okadaic acid
| [General Description]
Calcineurin (CaN) comprises CaN A and CaN B subunits. It exists as a heterodimer with a calmodulin-binding domain, catalytic site, a CaN B binding domain, and an autoinhibitory domain. | [Biochem/physiol Actions]
Calcineurin is a cyclosporin-sensitive, calcium-regulated, serine-threonine protein phosphatase with broad substrate specificity. It is the major calmodulin-binding protein found in the brain. First identified as an inhibitor of the calmodulin activation of phosphodiesterase 3′:5′ cyclic nucleotide (PDE), calcineurin has similar effects on adenylate cyclase. Serves as a key enzyme involved in T-cell activation. Also involved in the hyperphosphorylation of tau protein in Alzheimer′s disease and has been shown to prevent calpain-mediated proteolysis of tau in differentiated PC12 cells. |
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Sigma-Aldrich
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