| Identification | Back Directory | [Name]
MANNAN | [CAS]
9036-88-8 | [Synonyms]
Ailes
K-41K1
MANNAN
D-Mannan
NSC 307194
NSC 174481
NSC 174479
NSC 174478
NSC 174477
NSC 174473
Mannan
Tmac Mannan
MANNAN, YEAST
Mannan from Carob seed
MANNAN FROM FROM SACCHAROMYCES CEREV
mannan from saccharomyces cerevisiae
MANNAN FROM SACCHAROMYCES CEREVESIAE | [MDL Number]
MFCD00131574 |
| Chemical Properties | Back Directory | [refractive index ]
78.5 ° (C=1.4, H2O) | [storage temp. ]
2-8°C
| [form ]
powder
| [color ]
Off-white to light yellow | [biological source]
Saccharomyces cerevisiae | [optical activity]
[α]25/D 73 to 82 °, c =1% (w/v) in water | [Water Solubility ]
water: ~50g/L | [Merck ]
5744 | [CAS DataBase Reference]
9036-88-8 |
| Hazard Information | Back Directory | [Uses]
Mannan from Saccharomyces cerevisiae has been used in a study to assess nonopsonic uptake of Mycobacterium avium complex by human monocytes and alveolar macrophages. It has also been used in a study to investigate new lectins from bulbs of Croccus sativum. | [General Description]
Mannan from Saccharomyces cerevisiae is a simple polysaccharide. | [Biological Activity]
Mannan exhibits several biological propertiesincluding antiproliferativeantioxidantand immunomodulatory. It is used as a hardener ingredient and as an emulsion stabilizer. Mannan is also involved in the inhibition of pathogen adherenceregulation of bacterial growthand enhancement of the immune response. | [in vivo]
Mannan (50-500 ppm; p.o., dietary; daily; 4 weeks) reduces Aflatoxin B1 (HY-N6615)-induced toxicity in mice, as evidenced by increased body weight, decreased rate of normochromatic erythrocytes with micronuclei, and decreased rate of sister chromatid exchanges[2].
Mannan (50-100 mg/kg; i.p.; 2-5 times) reduces serum levels of low-density lipoprotein (LDL), cholesterol, and triglycerides in mice with acute dyslipidemia induced by poloxamer 407 (HY-D1005)[4].
| Animal Model: | Male CBA/Lac mice (2.5-3-month-old, weighing 22-25 g), acute lipemia induced by poloxamer 407 model[4] | | Dosage: | 50 mg/kg, 100 mg/kg | | Administration: | Intraperitoneal injection, 5 times at 50 mg/kg every other day or 2 times at 100 mg/kg with 1-day interval | | Result: | Reduced the levels of triglyceride, atherogenic LDL, and total cholesterol in the serum at 50 mg/kg and 100 mg/kg.
Decreased the triglyceride concentration in the liver.
Increased the lability of lysosomal membranes in the liver and elevated the serum activity of chitotriosidase, a marker of macrophage activation.
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| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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