| Identification | Back Directory | [Name]
2-Methyl-tetrahydro-pyran-4-ol | [CAS]
89791-47-9 | [Synonyms]
2-methyloxan-4-ol
2-Methyl-tetrahydro-pyran-4-ol
2-Methyltetrahydro-2H-pyran-4-ol
4-Hydroxy-2-methyltetrahydropyran
2H-Pyran-4-ol, tetrahydro-2-methyl- | [Molecular Formula]
C6H12O2 | [MDL Number]
MFCD16877672 | [MOL File]
89791-47-9.mol | [Molecular Weight]
116 |
| Hazard Information | Back Directory | [Uses]
2-Methyl-tetrahydro-pyran-4-ol is an important building block for synthesizing many kinds of organic matter, such as synthesis 2-methyloxan-4-one. | [Synthesis]
By the procedure of Ernst Hanschke (Chem. Ber., 1955, 88, 1053-1059), the acetaldehyde (1 equiv) and 3-buten-l-ol (1 equiv) are combined with 20% H2SO4 (10 vol) in a pressure tube. The tube was sealed and the reaction mixture was heated to 80 °C for 3 h. Reaction progress is monitored by TLC. After that, the reaction mixture is allowed to cool to rt, carefully neutralized (pH 8-9) by the coned ammonia, and extracted with EtOAc (3 x 5 vol). The combined organic phases are dried (Na2SO4), filtered, and the filtrate coned in vacuo providing the desired product 2-Methyl-tetrahydro-pyran-4-ol.
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