| Identification | Back Directory | [Name]
N'-(3-acetamidophenyl)-N-[2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl]oxamide | [CAS]
897613-29-5 | [Synonyms]
S1QEL
S1QEL1.1
N1-(3-acetamidophenyl)-N2-(2-(4-methyl-2-(p-tolyl)thiazol-5-yl)ethyl)oxalamide
N'-(3-acetamidophenyl)-N-[2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl]oxamide | [Molecular Formula]
C23H24N4O3S | [MDL Number]
MFCD07644661 | [MOL File]
897613-29-5.mol | [Molecular Weight]
436.53 |
| Chemical Properties | Back Directory | [density ]
1.300±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 3 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 2 mg/ml | [form ]
A crystalline solid | [pka]
11.19±0.70(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
S1QEL1.1 is a small molecule that suppresses superoxide production during reverse electron transport through the IQ site of the mitochondrial respiratory complex I (IC50 = 70 nM) without affecting oxidative phosphorylation. It diminishes endogenous oxidative damage in primary astrocytes, reduces stress-induced signaling in a cardiomyocyte cell model, and protects against ischemia-reperfusion injury in perfused mouse heart. |
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| Company Name: |
Merck KGaA
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| Tel: |
(+86) 21 2033 8288 |
| Website: |
http://www.sigmaaldrich.cn |
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