| Identification | Back Directory | [Name]
STF-118804 | [CAS]
894187-61-2 | [Synonyms]
CS-1510
STF-118804
AGN-PC-0329XY
AKOS001906141
MCULE-5035356713
AGN-PC-0329XY; AKOS001906141; MCULE-5035356713; STF-118804
STF-118804, AGN-PC-0329XY, AKOS001906141, MCULE-5035356713
4-(5-methyl-4-((phenylsulfonyl)methyl)oxazol-2-yl)-N-(pyridin-3-ylmethyl)benzamide
4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide
Benzamide, 4-[5-methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)-
4-[5-methyl-4-[(4-methylphenyl)sulfonylmethyl]-1,3-oxazol-2-yl]-N-(pyridin-3-ylmethyl)benzamide | [Molecular Formula]
C25H23N3O4S | [MDL Number]
MFCD14918065 | [MOL File]
894187-61-2.mol | [Molecular Weight]
461.53 |
| Chemical Properties | Back Directory | [Melting point ]
187-190°C | [density ]
1.281±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.00±0.46(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
STF-118804 is a highly specific NAMPT inhibitor, improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia, and targets leukemia stem cells. | [Biological Activity]
STF-118804 displays pancreatic ductal adenocarcinoma (PDAC) growth reducing potential in combination with chemotherapeutic drugs.''STF-118804 is a highly specific and potent NAMPT (nicotinamide phosphoribosyl transferase) inhibitor th at reduces the viability of most B-ALL cell lines. STF 118804 induces leukemia cell apoptosis including leukemia initiating (stem) cells. STF 118804 improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia. | [storage]
Store at -20°C |
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