| Identification | Back Directory | [Name]
FACTOR XIIA SUBSTRATE DIHYDROCHLORIDE | [CAS]
88467-45-2 | [Synonyms]
SUC-AAPF-AMC
FACTOR XIIA SUBSTRATE
Z-LYS-PHE-ARG-PNA 2HCL
SUC-ALA-ALA-PRO-PHE-MCA
SUC-ALA-ALA-PRO-PHE-AMC
Z-LYS-PHE-ARG-PNA DIHYDROCHLORIDE
Suc-Ala-Ala-Pro-Phe-AMC≥ 99% (HPLC)
FACTOR XIIA SUBSTRATE DIHYDROCHLORIDE
CHYMOTRYPSIN SUBSTRATE II, FLUOROGENIC
5:PN:WO0197794 SEQID:34 claimed protein
SUC-ALA-ALA-PRO-PHE-7-AMINO-4-METHYLCOUMARIN
N-SUCCINYL-ALA-ALA-PRO-PHE 7-AMIDO-4-METHYLCOUMARIN
N-SUCCINYL-ALA-ALA-PRO-PHE 7-AMIDO-4-*ME THYLCOUMARI
succinylalanylalanyl-prolyl-phenylalanine-4-methylcoumaryl-7-amide
Chymotrypsin Substrate II, Fluorogenic - CAS 88467-45-2 - Calbiochem
SUCCINYL-L-ALANYL-L-ALANYL-L-PROLYL-L-PHENYLALANINE 4-METHYLCOUMARYL-7-AMIDE
L-Phenylalaninamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-2-[(4-methyl-2-oxochromen-7-yl)amino]-3-phenylpropanoyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid | [Molecular Formula]
C34H39N5O9 | [MDL Number]
MFCD00080246 | [MOL File]
88467-45-2.mol | [Molecular Weight]
661.7 |
| Chemical Properties | Back Directory | [Boiling point ]
1093.0±65.0 °C(Predicted) | [density ]
1.347±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Clear, colorless solution (10 mg/mL in Methanol) | [form ]
White lyophilized solid | [pka]
4.69±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Chymotrypsin Substrate II, Fluorogenic finds widespread utility across diverse scientific research applications, encompassing the exploration of protein-protein interactions, enzyme kinetics, and receptor binding. Notably, its cost-effectiveness and user-friendly nature render it an appealing choice for researchers. Additionally, this peptide has been instrumental in delving into the intricate world of cell signaling pathways and unraveling the mechanisms governing gene expression regulation. It is postulated to function as a substrate for enzymes while also engaging with receptors. The prevailing belief suggests that the peptide effectively binds to specific receptors, subsequently triggering their activation and instigating consequential alterations in cellular signaling pathways. | [Chemical Properties]
White powder | [Uses]
Chymotrypsin Substrate II, Fluorogenic (cas# 88467-45-2) is a compound useful in organic synthesis. | [Uses]
Fluorogenic substrate for chymotrypsin. | [Biological Activity]
Sensitive fluorogenic substrate for the quantitative determination of chymotrypsin activity (excitation maximum: ~380 nm; emission maximum: ~460 nm). | [References]
[1] G B IRVINE C H W M Ennis. Visual detection of peptidase activity using fluorogenic substrates in a microtiter plate assay.[J]. Analytical biochemistry, 1990, 185 2: 304-307. DOI:10.1016/0003-2697(90)90298-n.
[2] LASZLO GRAF. Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin[J]. Biochemistry Biochemistry, 1987, 26 9: 2616-2623. DOI:10.1021/bi00383a031.
[3] OSHIMA G. Interaction of alpha-chymotrypsin with dimyristoyl phosphatidylcholine vesicles.[J]. Journal of biochemistry, 1984, 95 4: 1131-1136. DOI:10.1093/oxfordjournals.jbchem.a134701.
[4] OSHIMA G. Stimulation by phospholipid vesicles of proteolysis of egg white lysozyme by chymotrypsin.[J]. Journal of biochemistry, 1983, 5 1: 1615-1620. DOI:10.1093/OXFORDJOURNALS.JBCHEM.A134509. |
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