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ChemicalBook--->CAS DataBase List--->88349-90-0

88349-90-0

88349-90-0 Structure

88349-90-0 Structure
IdentificationBack Directory
[Name]

ST072042
[CAS]

88349-90-0
[Synonyms]

A2793
ST072042
ethyl [(5-chloroquinolin-8-yl)oxy]acetate
ethyl 2-(5-chloroquinolin-8-yl)oxyacetate
ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate
ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate
2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester
Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester
[Molecular Formula]

C13H12ClNO3
[MDL Number]

MFCD04275530
[MOL File]

88349-90-0.mol
[Molecular Weight]

265.69
Chemical PropertiesBack Directory
[Boiling point ]

393.4±27.0 °C(Predicted)
[density ]

1.291±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 100 mg/mL (376.38 mM)
[form ]

Solid
[pka]

1.97±0.29(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is a TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK .
[in vitro]

A2793 (100 μM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
It inhibits TASK-1 (100 μM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences TREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.

[target]

TargetValue
mTRESK
(Cell-free assay)
6.8 μM
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