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ChemicalBook--->CAS DataBase List--->882268-69-1

882268-69-1

882268-69-1 Structure

882268-69-1 Structure
IdentificationBack Directory
[Name]

HIF-2a Translation Inhibitor 76
[CAS]

882268-69-1
[Synonyms]

HIF-2α-IN-4
HIF-2a translation inhibitor
HIF-2a Translation Inhibitor 76
[Molecular Formula]

C9H9N3O4S2
[MDL Number]

MFCD30861484
[MOL File]

882268-69-1.mol
[Molecular Weight]

287.32
Chemical PropertiesBack Directory
[Boiling point ]

454.3±55.0 °C(Predicted)
[density ]

1.49±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 5mg/mL
[form ]

Solid
[pka]

5.38±0.10(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing[1].
[Biological Activity]

HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5’UTR iron-responsive element to oxygen sensing[1]. HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1].HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1].
[References]

[1]. Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5’UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.
Spectrum DetailBack Directory
[Spectrum Detail]

HIF-2a Translation Inhibitor 76(882268-69-1)1HNMR
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