| Identification | Back Directory | [Name]
Larazotide | [CAS]
881851-50-9 | [Synonyms]
Larazotide acetate
LARAZOTIDE ACETATE (> 90%)
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH | [Molecular Formula]
C34H59N9O12 | [MDL Number]
MFCD31630844 | [MOL File]
881851-50-9.mol | [Molecular Weight]
785.885 |
| Hazard Information | Back Directory | [Uses]
Larazotide Acetate is a selective α3β4* neuronal nicotinic ACh receptor antagonist. | [Biological Activity]
Larazotide acetate (AT1001) is a Zonulin receptor antagonista tight junction modulator. Larazotide inhibition of zonulin results in reducing trafficking across epithelial cells in the intestines and reducing intestinal permeability and "leaky gut," thought to be a gateway to multiple autoimmune diseasesincluding celiac diseaseirritable bowel syndrome (IBS)inflammatory bowel diseases (IBDCrohnμs and ulcerative colitis)type 1 diabetes mellitus (T1DM)nonalcoholic steatohepatitis (NASH)chronic kidney disease (CKD) and several others. It has been shown to inhibit the effect of inflammatory cytokines such as tumor necrosis factor (TNF-alpha) and interleukin (IL-4)blocking their increase of intestinal epithelial permeability. | [storage]
Store at -20°C |
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