| Identification | Back Directory | [Name]
AMD 070 hydrochloride | [CAS]
880549-30-4 | [Synonyms]
AMD-070 HCl
Mavorixafor HCl
AMD070 hydrochloride
AMD 070 hydrochloride
AMD-070 (hydrochloride)
AMD-070 (HCl 75%(w/w%))
AMD-11070 HYDROCHLORIDE
Mavorixafor (AMD-070) triHCl
AMD-070 hydrochloride(Mavorixafor)
AMD070 HYDROCHLORIDE; AMD 070 HYDROCHLORIDE
N1-(1H-Benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine hydrochloride
N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine monohydrochloride | [Molecular Formula]
C21H28ClN5 | [MDL Number]
MFCD23160058 | [MOL File]
880549-30-4.mol | [Molecular Weight]
385.94 |
| Hazard Information | Back Directory | [Uses]
N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine Monohydrochloride is a potent and selective antagonist of CXCR4. It is also an inhibitor of X4-tropic HIV virus. | [Biological Activity]
AMD070 (AMD11070) is an orally activereversible and selective CXCR4 (CD184fusin) antagonist (IC50 = 13 nM against 100 pM 125I-SDF-1α for binding human CD+/CXCR4+ CEM-CCRF cells) th at inhibits HIV-1 replication in cultures (IC50/host cells = 2 nM/MT-4 and 26 nM/PBMCs; T-tropic HIV-1NL4.3 strain) with no host cytotoxicity even at concentrations above 23 μM. | [in vivo]
Mavorixafor (2 mg/kg; po; once a day; for 49 days) hydrochloride significantly inhibits the lung metastasis of B88 SDF 1 cells in nude mice[2]. | Animal Model: | BALB/c nude mice (8 weeks of age) injected with B88-SDF-1 cells[2] | | Dosage: | 2 mg/kg | | Administration: | Oral administration; once a day; for 49 days | | Result: | A significant reduction in the number of metastatic lung nodules was observed in the mice. |
| [IC 50]
125I-CXCL12-CXCR4: 13 nM (IC50); HIV-1 (NL4.3 strain): 1 nM (IC50, In MT-4 cells); HIV-1 (NL4.3 strain): 9 nM (IC50, In PBMCs); HIV-1 (NL4.3 strain): 3 nM (IC90, In MT-4 cells); HIV-1 (NL4.3 strain): 26 nM (IC90, In PBMCs) |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
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