| Identification | Back Directory | [Name]
CNT2 inhibitor-1 | [CAS]
880155-70-4 | [Synonyms]
CNT2 inhibitor-1
Adenosine, 8-[([1,1'-biphenyl]-4-ylmethyl)amino]- (9CI) | [Molecular Formula]
C23H24N6O4 | [MDL Number]
MFCD31746895 | [MOL File]
880155-70-4.mol | [Molecular Weight]
448.47 |
| Chemical Properties | Back Directory | [Boiling point ]
807.5±75.0 °C(Predicted) | [density ]
1.57±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 75 mg/mL (167.24 mM) | [form ]
Solid | [pka]
13.07±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2. | [Biological Activity]
Primary Target
hCNT2''Reversible: yes''Target IC50: 640 nM in COS-7 cells | [References]
[1] Tatani K, et al. Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett. 2015 Jan 28;6(3):244-8. DOI:10.1021/ml500343r |
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