| Identification | Back Directory | [Name]
Aurora Kinase Inhibitor III | [CAS]
879127-16-9 | [Synonyms]
AKI-7169
Aurora Kinase Inhibitor 3
Aurora Kinase Inhibitor III
AKI-7169(Aurora Kinase Inhibitor III)
Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem
N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide
Cyclopropanecarboxamide, N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide >=98% (HPLC), solid | [Molecular Formula]
C21H18F3N5O | [MDL Number]
MFCD09265250 | [MOL File]
879127-16-9.mol | [Molecular Weight]
413.4 |
| Chemical Properties | Back Directory | [density ]
1.456±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: <2mg/mL | [form ]
White solid | [pka]
14.51±0.70(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [General Description]
A cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of Aurora A (IC50 = 42 nM). At higher concentrations, also inhibits the activities of other kinases, such as Lck, Bmx, IGF-1R, and Syk (IC50 = 131, 386, 591, and 887 nM, respectively). | [Biochem/physiol Actions]
Target IC50: 42 nM against Aurora A; 131, 386, 591, and 887 nM, against Lck, Bmx, IGF-1R, and Syk , respectively |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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