| Identification | Back Directory | [Name]
Aurora Kinase Inhibitor III | [CAS]
879127-16-9 | [Synonyms]
AKI-7169
Aurora Kinase Inhibitor 3
Aurora Kinase Inhibitor III
AKI-7169(Aurora Kinase Inhibitor III)
Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem
N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide
Cyclopropanecarboxamide, N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide >=98% (HPLC), solid | [Molecular Formula]
C21H18F3N5O | [MDL Number]
MFCD09265250 | [MOL File]
879127-16-9.mol | [Molecular Weight]
413.4 |
| Chemical Properties | Back Directory | [density ]
1.456±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: <2mg/mL | [form ]
White solid | [pka]
14.51±0.70(Predicted) | [color ]
white | [Water Solubility ]
H2O: <2mg/mL
DMSO: >7mg/mL |
| Hazard Information | Back Directory | [Uses]
Aurora kinase inhibitor-3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50 of >10 μM. Aurora kinase inhibitor-3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket[1]. | [General Description]
A cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of Aurora A (IC50 = 42 nM). At higher concentrations, also inhibits the activities of other kinases, such as Lck, Bmx, IGF-1R, and Syk (IC50 = 131, 386, 591, and 887 nM, respectively). | [Biochem/physiol Actions]
Target IC50: 42 nM against Aurora A; 131, 386, 591, and 887 nM, against Lck, Bmx, IGF-1R, and Syk , respectively | [IC 50]
Aurora A: 42 nM (IC50) | [References]
[1] Tari LW, et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinitydisubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91. DOI:10.1016/j.bmcl.2006.10.086 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|