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ChemicalBook--->CAS DataBase List--->87779-49-5

87779-49-5

87779-49-5 Structure

87779-49-5 Structure
IdentificationBack Directory
[Name]

BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT
[CAS]

87779-49-5
[Synonyms]

Bz-VGR-AMC
Bz-Val-Gly-Arg-AMC
BZ-VAL-GLY-ARG-AMC TFA SALT
Bz-Val-Gly-Arg-AMC (I-1085.0050)
BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT
N-Benzoyl-L-valylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide
L-Argininamide, N-benzoyl-L-valylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
N-[(2S)-1-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]benzamide
[Molecular Formula]

C30H37N7O6
[MDL Number]

MFCD02259608
[MOL File]

87779-49-5.mol
[Molecular Weight]

591.66
Chemical PropertiesBack Directory
[storage temp. ]

-15°C
[solubility ]

Soluble in DMSO.
[form ]

White powder.
[color ]

White
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Hazard InformationBack Directory
[Description]

Bz-VGR-AMC (87779-49-5) may be used for measuring the trypsin-like activity of the 20S proteasome, in combination with Suc-LLVY-AMC (Cat.# 10-2971, for assaying its chymotrypsin-like activity) and Z-LLE-AMC, (for determining its PGPH activity). Fluorogenic substrate. Ex.: 380nm Em.: 460nm.
[Uses]

Bz-Val-Gly-Arg-AMC is a bioactive compound used in assaying the degree of inhibition conferred by PS-341, a potent peptidylboronic acid with anticancer properties.
[References]

1) Gillardon?et al. (2007),?The 20S proteasome isolated from Alzheimer’s disease brain shows post-translational modifications but unchanged proteolytic activity; J. Neurochem.,?101?1483 2) Kim?et al. (2002),?Navigation inside a protease: substrate selection and product exit in tricorn protease from Thermoplasma acidophilum; J. Mol. Biol.,?324?1041 3) Dahlmann?et al. (2000),?Different proteasome subtypes in a single tissue exhibit different enzymatic properties; J. Mol. Biol.,?303?643 4) Lightcap?et al. (2000),?Proteasome inhibition measurements: clinical application; Clin. Chem.,?46?673
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