| Identification | Back Directory | [Name]
F-AMidine | [CAS]
877617-45-3 | [Synonyms]
F-AMidine
N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide | [Molecular Formula]
C14H19FN4O2 | [MDL Number]
MFCD28138492 | [MOL File]
877617-45-3.mol | [Molecular Weight]
294.32 |
| Hazard Information | Back Directory | [Uses]
An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively). | [Definition]
ChEBI: F-Amidine is a N-acylglycine. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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